NADPH-dependent ROS accumulation contributes to the impaired osteogenic differentiation of periodontal ligament stem cells under high glucose conditions

NADPH-dependent ROS accumulation contributes to the impaired osteogenic differentiation of periodontal ligament stem cells under high glucose conditions

Diabetes mellitus is an established risk factor for periodontal disease that can aggravate the severity of periodontal inflammation and accelerate periodontal destruction. The chronic high glucose condition is a hallmark of diabetes-related pathogenesis, and has been demonstrated to impair the osteo...

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Bibliographic Details
Main Authors: Yi-lin Zhang, Ying An, Li-Juan Sun, Hong-Lei Qu, Xuan Li, Xiao-Tao He, Rui-Xin Wu, Fa-Ming Chen, Bei-Min Tian, Yuan Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
high glucose
osteogenic differentiation
ROS
NADPH
periodontal tissue regeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1152845/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1152845/full

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