Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid pe...

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Bibliographic Details
Main Authors: Shengyou Li, Xue Gao, Yi Zheng, Yujie Yang, Jianbo Gao, Dan Geng, Lingli Guo, Teng Ma, Yiming Hao, Bin Wei, Liangliang Huang, Yitao Wei, Bing Xia, Zhuojing Luo, Jinghui Huang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Ferroptosis
UBA52
Ferroportin
Ubiquitination
Hydralazine
Peripheral nerve injury
Online Access:http://www.sciencedirect.com/science/article/pii/S209517792300196X

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http://www.sciencedirect.com/science/article/pii/S209517792300196X

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