Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52

A major impedance to neuronal regeneration after peripheral nerve injury (PNI) is the activation of various programmed cell death mechanisms in the dorsal root ganglion. Ferroptosis is a form of programmed cell death distinguished by imbalance in iron and thiol metabolism, leading to lethal lipid pe...

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Main Authors: Shengyou Li, Xue Gao, Yi Zheng, Yujie Yang, Jianbo Gao, Dan Geng, Lingli Guo, Teng Ma, Yiming Hao, Bin Wei, Liangliang Huang, Yitao Wei, Bing Xia, Zhuojing Luo, Jinghui Huang
格式: 文件
语言:English
出版: Elsevier 2024-01-01
丛编:Journal of Pharmaceutical Analysis
主题:
Ferroptosis
UBA52
Ferroportin
Ubiquitination
Hydralazine
Peripheral nerve injury
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