Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss

Cell death-inducing cytotoxicity in truncated KCNQ4 variants associated with DFNA2 hearing loss

KCNQ4 encodes the homotetrameric voltage-dependent potassium ion channel Kv7.4, and is the causative gene for autosomal dominant nonsyndromic sensorineural hearing loss, DFNA2. Dominant-negative inhibition accounts for the observed dominant inheritance of many DFNA2-associated KCNQ4 variants. In add...

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Bibliographic Details
Main Authors: Takashi Kojima, Koichiro Wasano, Satoe Takahashi, Kazuaki Homma
Format: Article
Language:English
Published: The Company of Biologists 2021-11-01
Series:Disease Models & Mechanisms
Subjects:
kcnq family
kcnq4
kv7.4
potassium channel
hereditary hearing loss
dfna2
Online Access:http://dmm.biologists.org/content/14/11/dmm049015

Internet

http://dmm.biologists.org/content/14/11/dmm049015

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