Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer

Systemic Ketone Replacement Does Not Improve Survival or Cancer Cachexia in Mice With Lung Cancer

Cachexia is a debilitating comorbidity affecting many lung cancer patients. We have previously found that cachectic mice with lung cancer have reduced serum ketone body levels due to low PPARα activity in the liver. Restoring hepatic PPARα activity with fenofibrate increased circulating ketones and...

Full description

Bibliographic Details
Main Authors: Henning Tim Langer, Shakti Ramsamooj, Roger J. Liang, Rahul Grover, Seo-Kyoung Hwang, Marcus DaSilva Goncalves
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
ketogenic diet (KD)
ketone ester supplementation
cachexia
lung cancer
PPAR alpha
beta hydroxybutyrate
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.903157/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.903157/full

Similar Items