Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner

Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner

GNAS encodes the stimulatory G protein alpha-subunit (Gsα) and its large variant XLαs. Studies have suggested that XLαs is expressed exclusively paternally. Thus, XLαs deficiency is considered to be responsible for certain findings in patients with paternal GNAS mutations, such as pseudo-pseudohypop...

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Bibliographic Details
Main Authors: Qiuxia Cui, Cagri Aksu, Birol Ay, Claire E. Remillard, Antonius Plagge, Mina Gardezi, Margaret Dunlap, Louis C. Gerstenfeld, Qing He, Murat Bastepe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
GNAS
stimulatory G protein
imprinting
osteoblasts
bone marrow stromal cells
fibrous dysplasia of bone
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.680537/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.680537/full

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