Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling

Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling

BackgroundConstant supply of oxygen is crucial for multicellular tissue homeostasis and energy metabolism in cardiac tissue. As a first response to acute hypoxia, endothelial cells (ECs) promote recruitment and adherence of immune cells to the dysbalanced EC barrier by releasing inflammatory mediato...

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Bibliographic Details
Main Authors: Arne Schmidt, Maximilian Fuchs, Stevan D. Stojanović, Chunguang Liang, Kevin Schmidt, Mira Jung, Ke Xiao, Jan Weusthoff, Annette Just, Angelika Pfanne, Jörg H. W. Distler, Thomas Dandekar, Jan Fiedler, Thomas Thum, Meik Kunz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypoxia
transcription factor
endothelial
angiogenesis
promoter profiling
signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.877450/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.877450/full

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