Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors

Novel 13α-estrone derivatives were synthesized by Sonogashira coupling. Transformations of 2- or 4-iodo regioisomers of 13α-estrone and its 3-methyl ether were carried out under different conditions in a microwave reactor. The 2-iodo isomers were reacted with para-substituted phenylacetylenes using...

Full description

Bibliographic Details
Main Authors: Ildikó Bacsa, Rebeka Jójárt, János Wölfling, Gyula Schneider, Bianka Edina Herman, Mihály Szécsi, Erzsébet Mernyák
Format: Article
Language:English
Published: Beilstein-Institut 2017-06-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
benzofuran
13α-estrone
17β-HSD1 inhibition
partial saturation
Sonogashira coupling
Online Access:https://doi.org/10.3762/bjoc.13.126

Internet

https://doi.org/10.3762/bjoc.13.126

Similar Items