Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations

Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations

Summary: Background: Multiple sclerosis is characterised by inflammation, oligodendrocyte loss and axonal demyelination and shows an additional impact on astrocytes, and their polarization. Although a certain degree of spontaneous myelin repair can be observed, disease progression, and aging impair...

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Bibliographic Details
Main Authors: Markley Silva Oliveira Junior, Jessica Schira-Heinen, Laura Reiche, Seulki Han, Vanessa Cristina Meira de Amorim, Isabel Lewen, Joel Gruchot, Peter Göttle, Rainer Akkermann, Kasum Azim, Patrick Küry
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:EBioMedicine
Subjects:
Reactive astrogliosis
Multiple sclerosis
Corticosteroids
Cuprizone
Remyelination
Subventricular zone
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422003863

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http://www.sciencedirect.com/science/article/pii/S2352396422003863

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