Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

Matrix conditions and KLF2-dependent induction of heme oxygenase-1 modulate inhibition of HCV replication by fluvastatin.

HMG-CoA-reductase-inhibitors (statins) have been shown to interfere with HCV replication in vitro. We investigated the mechanism, requirements and contribution of heme oxygenase-1(HO-1)-induction by statins to interference with HCV replication.HO-1-induction by fluva-, simva-, rosuva-, atorva- or pr...

Full description

Bibliographic Details
Main Authors: Andrea Wuestenberg, Janine Kah, Katrin Singethan, Hüseyin Sirma, Amelie Dorothea Keller, Sergio René Perez Rosal, Jörg Schrader, Christine Loscher, Tassilo Volz, Ralf Bartenschlager, Volker Lohmann, Ulrike Protzer, Maura Dandri, Ansgar W Lohse, Gisa Tiegs, Gabriele Sass
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4011762?pdf=render

Internet

http://europepmc.org/articles/PMC4011762?pdf=render

Similar Items