Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3β Pathway

Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3β Pathway

Background/Aims: Pterostilbene (Pts), a natural dimethylated analog of resveratrol from blueberries, exerts antioxidative and anti-apoptotic effects in various diseases. This study aims to investigate the protective effects and mechanism of Pts against acetaminophen (APAP)-induced hepatotoxicity in...

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Bibliographic Details
Main Authors: Xiaoye Fan, Lidong Wang, Jingbo Huang, Hongming Lv, Xuming Deng, Xinxin Ci
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Pterostilbene
Acetaminophen
Hepatotoxicity
Nrf2
AMPK/Akt/GSK3β pathway
Online Access:https://www.karger.com/Article/FullText/493655

Internet

https://www.karger.com/Article/FullText/493655

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