Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats

Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats

In the kidney, reabsorption via the epithelial sodium channel (ENaC) is involved in long-term blood pressure control. Previously we demonstrated that ENaC hyperactivity is associated with development of salt-sensitive (SS) hypertension in Dahl SS rats. AMP-activated kinase (AMPK), playing a role in...

Full description

Bibliographic Details
Main Authors: Tengis S. Pavlov, Vladislav Levchenko, Daria V. Ilatovskaya, Hui Li, Oleg Palygin, Nuria M. Pastor-Soler, Kenneth R. Hallows, Alexander Staruschenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Physiology
Subjects:
hypertension
salt sensitivity
AMPK
metformin
AICAR
ENaC
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00227/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00227/full

Similar Items