Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways.

Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways.

To discover vulnerabilities associated with dermokine (DMKN) as a new trigger of the epithelial-mesenchymal transition (EMT) -driven melanoma, we undertook a genome-wide genetic screening using transgenic. Here, we showed that DMKN expression could be constitutively increased in human malignant mela...

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Bibliographic Details
Main Authors: Wenqiong Ma, Zexiu Wu, Mazaher Maghsoudloo, Iqra Ijaz, Marzieh Dehghan Shasaltaneh, Yuqin Zhang, Qiao Weng, Junjiang Fu, Saber Imani, Qing Lian Wen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0285806&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0285806&type=printable

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