Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity

Smad4 regulates TGF-β1-mediated hedgehog activation to promote epithelial-to-mesenchymal transition in pancreatic cancer cells by suppressing Gli1 activity

Pancreatic cancer (PC) is an aggressive and metastatic gastrointestinal tumor with a poor prognosis. Persistent activation of the TGF-β/Smad signaling induces PC cell (PCC) invasion and infiltration via epithelial-to-mesenchymal transition (EMT). Hedgehog signaling is a crucial pathway for the devel...

Full description

Bibliographic Details
Main Authors: Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Mengsi Wang, Chaoyue Chen, Lili Xie, Yuanyuan Gao, Wangjian Li, Yongheng Bai, Chunjing Lin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Pancreatic cancer
Epithelial-mesenchymal transition (EMT)
TGF-β1
Smad4
Gli1
Hedgehog signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037024000631

Internet

http://www.sciencedirect.com/science/article/pii/S2001037024000631

Similar Items