Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish.

Conditional mutagenesis by oligonucleotide-mediated integration of loxP sites in zebrafish.

Many eukaryotic genes play essential roles in multiple biological processes in several different tissues. Conditional mutants are needed to analyze genes with such pleiotropic functions. In vertebrates, conditional gene inactivation has only been feasible in the mouse, leaving other model systems to...

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Bibliographic Details
Main Authors: Leonard Burg, Nicholas Palmer, Khrievono Kikhi, Evgeniya S Miroshnik, Helen Rueckert, Eleanor Gaddy, Carlee MacPherson Cunningham, Kenny Mattonet, Shih-Lei Lai, Rubén Marín-Juez, Richard B Waring, Didier Y R Stainier, Darius Balciunas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007754

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https://doi.org/10.1371/journal.pgen.1007754

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