Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors

Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors

Abstract Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T cell‐mediated protection are not well understood. The antigenic breadth and the immunodominance hierarchies of epitope‐specific CD8+ T cells...

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Bibliographic Details
Main Authors: Jet van denDijssel, Ruth R Hagen, Rivka deJongh, Maurice Steenhuis, Theo Rispens, Dionne M Geerdes, Juk Yee Mok, Angela HM Kragten, Mariël C Duurland, Niels JM Verstegen, S Marieke vanHam, Wim JE vanEsch, Klaas PJM vanGisbergen, Pleun Hombrink, Anja tenBrinke, Carolien E van deSandt
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Clinical & Translational Immunology
Subjects:
CD8+ T cells
convalescence
epitopes
immunodominance
infection
SARS‐CoV‐2
Online Access:https://doi.org/10.1002/cti2.1423

Internet

https://doi.org/10.1002/cti2.1423

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