Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes

Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes

Osteoarthritis (OA) is a common joint disease in the elderly population. Its development has been reported to be associated with cartilage degradation and inflammatory responses. Schisandrin A, a bioactive lignin in Schisandra sphenanthera, has shown its anti-inflammatory potential in various inflam...

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Bibliographic Details
Main Authors: Chang Tu, Xiaojian Huang, Yifan Xiao, Mingyu Song, Yongzhuang Ma, Jiyuan Yan, Hongbo You, Hua Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
Schisandrin A
osteoarthritis
iNOS
Cox-2
MMPs
ADAMTS5
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00041/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00041/full

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