Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange

Human Rad51 Protein Requires Higher Concentrations of Calcium Ions for D-Loop Formation than for Oligonucleotide Strand Exchange

Human Rad51 protein (HsRad51)-promoted DNA strand exchange, a crucial step in homologous recombination, is regulated by proteins and calcium ions. Both the activator protein Swi5/Sfr1 and Ca<sup>2+</sup> ions stimulate different reaction steps and induce perpendicular DNA base alignment...

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Bibliographic Details
Main Authors: Axelle Renodon-Corniere, Tsutomu Mikawa, Naoyuki Kuwabara, Kentaro Ito, Dmitri Levitsky, Hiroshi Iwasaki, Masayuki Takahashi
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
Rad51 protein
homologous recombination
DNA strand exchange
calcium ion
D-loop
Online Access:https://www.mdpi.com/1422-0067/25/7/3633

Internet

https://www.mdpi.com/1422-0067/25/7/3633

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