Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material

Ebola Virus Infections in Nonhuman Primates Are Temporally Influenced by Glycoprotein Poly-U Editing Site Populations in the Exposure Material

Recent experimentation with the variants of the Ebola virus that differ in the glycoprotein’s poly-uridine site, which dictates the form of glycoprotein produced through a transcriptional stutter, has resulted in questions regarding the pathogenicity and lethality of the stocks used to develop produ...

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Bibliographic Details
Main Authors: John C. Trefry, Suzanne E. Wollen, Farooq Nasar, Joshua D. Shamblin, Steven J. Kern, Jeremy J. Bearss, Michelle A. Jefferson, Taylor B. Chance, Jeffery R. Kugelman, Jason T. Ladner, Anna N. Honko, Dean J. Kobs, Morgan Q.S. Wending, Carol L. Sabourin, William D. Pratt, Gustavo F. Palacios, M. Louise M. Pitt
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
Ebola virus
Kikwit
filovirus
nonhuman primate
glycoprotein
RNA editing
pathogenesis
animal model
vaccine
therapeutic
Online Access:http://www.mdpi.com/1999-4915/7/12/2969

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http://www.mdpi.com/1999-4915/7/12/2969

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