Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity

Abstract TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and NUDT15 normal metabolizers, a score combining the ge...

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Bibliographic Details
Main Authors: Laura L. Daniel, Alyson L. Dickson, Jacy T. Zanussi, Tyne W. Miller‐Fleming, Peter S. Straub, Wei‐Qi Wei, W. Dale Plummer, William D. Dupont, Ge Liu, Prathima Anandi, Tyler S. Reese, Kelly A. Birdwell, Vivian K. Kawai, Adriana M. Hung, Nancy J. Cox, QiPing Feng, C. Michael Stein, Cecilia P. Chung
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13243

Internet

https://doi.org/10.1111/cts.13243

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