Rate Dependence on Inductive and Resonance Effects for the Organocatalyzed Enantioselective Conjugate Addition of Alkenyl and Alkynyl Boronic Acids to β-Indolyl Enones and β-Pyrrolyl Enones

Rate Dependence on Inductive and Resonance Effects for the Organocatalyzed Enantioselective Conjugate Addition of Alkenyl and Alkynyl Boronic Acids to β-Indolyl Enones and β-Pyrrolyl Enones

Two key factors bear on reaction rates for the conjugate addition of alkenyl boronic acids to heteroaryl-appended enones: the proximity of inductively electron-withdrawing heteroatoms to the site of bond formation and the resonance contribution of available heteroatom lone pairs to stabilize the dev...

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Bibliographic Details
Main Authors: Amy Boylan, Thien S. Nguyen, Brian J. Lundy, Jian-Yuan Li, Ravikrishna Vallakati, Sasha Sundstrom, Jeremy A. May
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
enantioselective conjugate addition
heterocycles
pyrrole
indole
Online Access:https://www.mdpi.com/1420-3049/26/6/1615

Internet

https://www.mdpi.com/1420-3049/26/6/1615

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