Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.

Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.

BACKGROUND: H5N1 influenza vaccines, including live intranasal, appear to be relatively less immunogenic compared to seasonal analogs. The main influenza virus surface glycoprotein hemagglutinin (HA) of highly pathogenic avian influenza viruses (HPAIV) was shown to be more susceptible to acidic pH t...

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Bibliographic Details
Main Authors: Brigitte M Krenn, Andrej Egorov, Ekaterina Romanovskaya-Romanko, Markus Wolschek, Sabine Nakowitsch, Tanja Ruthsatz, Bettina Kiefmann, Alexander Morokutti, Johannes Humer, Janina Geiler, Jindrich Cinatl, Martin Michaelis, Nina Wressnigg, Sanda Sturlan, Boris Ferko, Oleg V Batishchev, Andrey V Indenbom, Rong Zhu, Markus Kastner, Peter Hinterdorfer, Oleg Kiselev, Thomas Muster, Julia Romanova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072404?pdf=render

Internet

http://europepmc.org/articles/PMC3072404?pdf=render

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