MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing

MGA-seq: robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing

Abstract Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method — multiple genetic abnormality sequencing (MGA-Seq) — to simultaneously detect structural variation, copy number variation, single-nucleotide polymorphism, homo...

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Bibliographic Details
Main Authors: Da Lin, Yanyan Zou, Xinyu Li, Jinyue Wang, Qin Xiao, Xiaochen Gao, Fei Lin, Ningyuan Zhang, Ming Jiao, Yu Guo, Zhaowei Teng, Shiyi Li, Yongchang Wei, Fuling Zhou, Rong Yin, Siheng Zhang, Lingyu Xing, Weize Xu, Xiaofeng Wu, Bing Yang, Ke Xiao, Chengchao Wu, Yingfeng Tao, Xiaoqing Yang, Jing Zhang, Sheng Hu, Shuang Dong, Xiaoyu Li, Shengwei Ye, Zhidan Hong, Yihang Pan, Yuqin Yang, Haixiang Sun, Gang Cao
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Genome Biology
Subjects:
Extrachromosomal DNA (ecDNA)
Homogenously staining regions (HSRs)
Structural variation (SV)
Genomic abnormalities
Spatial chromatin conformation
Online Access:https://doi.org/10.1186/s13059-023-03081-x

Internet

https://doi.org/10.1186/s13059-023-03081-x

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