Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury

Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury

The type I interferon (TI-IFN) pathway regulates innate immunity, inflammation, and apoptosis during infection. However, the contribution of the TI-IFN pathway or upstream signaling pathways to tubular injury in kidney disease is poorly understood. Upon observing evidence of activation of upstream r...

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Bibliographic Details
Main Authors: Gina Córdoba-David, Jorge García-Giménez, Regiane Cardoso Castelo-Branco, Susana Carrasco, Pablo Cannata, Alberto Ortiz, Adrián M. Ramos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
TBK1/IKKε
type I interferon
kidney injury
TWEAK
LPS
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.987979/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.987979/full

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