Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy

Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy

The ATR-CHK1 pathway plays a fundamental role in the DNA damage response and is therefore an attractive target in cancer therapy. The antitumorous effect of ATR inhibitors is at least partly caused by synthetic lethality between ATR and various DNA repair genes. In previous studies, we have identifi...

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Dettagli Bibliografici
Autori principali: Hanna Elisabeth Schneider, Lisa-Maria Schmitt, Albert Job, Brigitte Lankat-Buttgereit, Thomas Gress, Malte Buchholz, Eike Gallmeier
Natura: Articolo
Lingua:English
Pubblicazione: Elsevier 2024-11-01
Serie:Neoplasia: An International Journal for Oncology Research
Soggetti:
Synthetic letality
ATR
POLA1
Colon cancer
S phase arrest
Apoptosis, Cancer therapy
Accesso online:http://www.sciencedirect.com/science/article/pii/S1476558624000800

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http://www.sciencedirect.com/science/article/pii/S1476558624000800

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