Additional cytosine inside mitochondrial C-tract D-loop as a progression risk factor in oral precancer cases

Introduction: Alterations inside Polycytosine tract (C-tract) of mitochondrial DNA (mtDNA) have been described in many different tumor types. The Poly-Cytosine region is located within the mtDNA D-loop region which acts as point of mitochondrial replication origin. A suggested pathogenesis is that i...

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Bibliographic Details
Main Authors: Rahul Pandey, Divya Mehrotra, Abbas Ali Mahdi, Rajiv Sarin, Pradnya Kowtal
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Oral Biology and Craniofacial Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2212426814000062