A systematic investigation of production of synthetic prions from recombinant prion protein

A systematic investigation of production of synthetic prions from recombinant prion protein

According to the protein-only hypothesis, infectious mammalian prions, which exist as distinct strains with discrete biological properties, consist of multichain assemblies of misfolded cellular prion protein (PrP). A critical test would be to produce prion strains synthetically from defined compone...

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Bibliographic Details
Main Authors: Christian Schmidt, Jeremie Fizet, Francesca Properzi, Mark Batchelor, Malin K. Sandberg, Julie A. Edgeworth, Louise Afran, Sammy Ho, Anjna Badhan, Steffi Klier, Jacqueline M. Linehan, Sebastian Brandner, Laszlo L. P. Hosszu, M. Howard Tattum, Parmjit Jat, Anthony R. Clarke, Peter C. Klöhn, Jonathan D. F. Wadsworth, Graham S. Jackson, John Collinge
Format: Article
Language:English
Published: The Royal Society 2015-01-01
Series:Open Biology
Subjects:
prion
prion disease
prion protein
prion amyloid
synthetic prions
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150165

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150165

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