Targeting Hydrogen Sulfide Modulates Dexamethasone-Induced Muscle Atrophy and Microvascular Rarefaction, through Inhibition of NOX4 and Induction of MGF, M2 Macrophages and Endothelial Progenitors

Targeting Hydrogen Sulfide Modulates Dexamethasone-Induced Muscle Atrophy and Microvascular Rarefaction, through Inhibition of NOX4 and Induction of MGF, M2 Macrophages and Endothelial Progenitors

Long-term use of Glucocorticoids produces skeletal muscle atrophy and microvascular rarefaction. Hydrogen sulfide (H2S) has a potential role in skeletal muscle regeneration. However, the mechanisms still need to be elucidated. This is the first study to explore the effect of Sodium hydrosulfide (NaH...

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Bibliographic Details
Main Authors: Mohamed Adel, Hassan Reda Hassan Elsayed, Mohammad El-Nablaway, Shereen Hamed, Amira Eladl, Samah Fouad, Eman Mohamad El Nashar, Mohammed Lafi Al-Otaibi, Mohammed R. Rabei
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
muscle atrophy
H2S
NaHS
MGF
NOX-4
Myostatin
Online Access:https://www.mdpi.com/2073-4409/11/16/2500

Internet

https://www.mdpi.com/2073-4409/11/16/2500

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