In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration

In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration

Abstract Background Low back pain (LBP) is predominantly caused by degeneration of the intervertebral disc (IVD) and central nucleus pulposus (NP) region. Conservative treatments fail to restore disc function, motivating the exploration of nucleic acid therapies, such as the use of microRNAs (miRNAs...

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Bibliographic Details
Main Authors: Tara Ní Néill, Marcos N. Barcellona, Niamh Wilson, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:JOR Spine
Subjects:
anti‐catabolism
cell penetrating peptides
cell therapies
microRNA
regeneration
Online Access:https://doi.org/10.1002/jsp2.1366

Internet

https://doi.org/10.1002/jsp2.1366

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