Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer’s disease

Alzheimer’s disease (AD) leads to progressive memory decline, and alterations in hippocampal function are among the earliest pathological features observed in human and animal studies. GABAergic interneurons (INs) within the hippocampus coordinate network activity, among which type 3 interneuron-spe...

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Bibliographic Details
Main Authors: Felix Michaud, Ruggiero Francavilla, Dimitry Topolnik, Parisa Iloun, Suhel Tamboli, Frederic Calon, Lisa Topolnik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-09-01
Series:eLife
Subjects:
hippocampus
memory
Alzheimer's disease
circuit
inhibition
disinhibition
Online Access:https://elifesciences.org/articles/95412

Internet

https://elifesciences.org/articles/95412

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