A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike protein fused to a modified single-chain human IgG1...

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Bibliographic Details
Main Authors: Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev, Farshad Guirakhoo
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
subunit vaccine
neutralizing antibody
protection
non-human primate
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2140608

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https://www.tandfonline.com/doi/10.1080/22221751.2022.2140608

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