Phosphatidylcholine Liposomes Down-Modulate CD4 Expression Reducing HIV Entry in Human Type-1 Macrophages

Phosphatidylcholine Liposomes Down-Modulate CD4 Expression Reducing HIV Entry in Human Type-1 Macrophages

A strategy adopted to combat human immunodeficiency virus type-1 (HIV-1) infection is based on interfering with virus entry into target cells. In this study, we found that phosphatidylcholine (PC) liposomes reduced the expression of the CD4 receptor in human primary type-1 macrophages but not in CD4...

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Bibliographic Details
Main Authors: Federica De Santis, Ana Borrajo Lopez, Sara Virtuoso, Noemi Poerio, Patrizia Saccomandi, Tommaso Olimpieri, Leonardo Duca, Lucia Henrici De Angelis, Katia Aquilano, Marco Maria D’Andrea, Stefano Aquaro, Alessandra Borsetti, Francesca Ceccherini-Silberstein, Maurizio Fraziano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
host-directed therapy
liposome
phosphatidylcholine
macrophage
HIV entry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.830788/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.830788/full

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