Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties

The precise mechanisms underlying the detrimental effects of early life adversity (ELA) on adult mental health remain still elusive. To date, most studies have exclusively targeted neuronal populations and not considered neuron-glia crosstalk as a crucially important element for the integrity of str...

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Bibliographic Details
Main Authors: Giulia Treccani, Hatice Yigit, Thomas Lingner, Vanessa Schleuβner, Franziska Mey, Michael A. van der Kooij, Malin Wennström, David P. Herzog, Matthias Linke, Markus Fricke, Michael J. Schmeisser, Gregers Wegener, Thomas Mittmann, Jacqueline Trotter, Marianne B. Müller
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Stress
Subjects:
Early life stress
NG2+ glia
Transcriptome
Scn7a
Nav-channels
Translational psychiatry
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289521000461

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http://www.sciencedirect.com/science/article/pii/S2352289521000461

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