Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults

Multiomics Analysis of Structural Magnetic Resonance Imaging of the Brain and Cerebrospinal Fluid Metabolomics in Cognitively Normal and Impaired Adults

IntroductionIntegrating brain imaging with large scale omics data may identify novel mechanisms of mild cognitive impairment (MCI) and early Alzheimer’s disease (AD). We integrated and analyzed brain magnetic resonance imaging (MRI) with cerebrospinal fluid (CSF) metabolomics to elucidate metabolic...

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Bibliographic Details
Main Authors: Ronald C. Eldridge, Karan Uppal, Mahsa Shokouhi, M. Ryan Smith, Xin Hu, Zhaohui S. Qin, Dean P. Jones, Ihab Hajjar
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
MRI imaging
metabolomics (OMICS)
multiomics analysis
mild cognition impairment
amino acids (AA)
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.796067/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2021.796067/full

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