Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration

Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration

Parkinson’s disease (PD) is the most common movement disorder, characterized by the progressive loss of dopaminergic neurons from the nigrostriatal system. Currently, there is no treatment that retards disease progression or reverses damage prior to the time of clinical diagnosis. Mesenchymal stem c...

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Bibliographic Details
Main Authors: Bárbara Mendes-Pinheiro, Jonas Campos, Ana Marote, Carina Soares-Cunha, Sarah L. Nickels, Anna S. Monzel, Jorge R. Cibrão, Eduardo Loureiro-Campos, Sofia C. Serra, Sandra Barata-Antunes, Sara Duarte-Silva, Luísa Pinto, Jens C. Schwamborn, António J. Salgado
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
mesenchymal stem cells
brain organoids
stem cell secretome
Parkinson’s disease
pre-clinical study
neurodegeneration
Online Access:https://www.mdpi.com/2073-4409/12/21/2565

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https://www.mdpi.com/2073-4409/12/21/2565

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