Neuroprotective effect and herbal-drug pharmacokinetic interaction of Gastrodia elata extract on valproic acid

Neuroprotective effect and herbal-drug pharmacokinetic interaction of Gastrodia elata extract on valproic acid

Valproic acid (VPA) is a widely used antiepileptic drug, and the herbal extract of Gastrodia elata exerts an anticonvulsant effect. However, few studies have investigated the pharmacokinetic and pharmacodynamic interactions between G. elata extract and VPA. We hypothesize that G. elata extract incre...

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Bibliographic Details
Main Authors: Ling Yang, Tung-Hu Tsai
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gastrodia elata extract
Valproic acid
Pilocarpine-induced epileptic rat model
Microdialysis
Herb-drug pharmacokinetic interaction
Herb-drug pharmacodynamic interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013270

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http://www.sciencedirect.com/science/article/pii/S0753332222013270

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