Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice

Hyperoxia but not high tidal volume contributes to ventilator-induced lung injury in healthy mice

Abstract Background Mechanical ventilation is a supportive therapy used to maintain respiratory function in several clinical and surgical cases but is always accompanied by lung injury risk due to improper treatment. We investigated how tidal volume and oxygen delivery would contribute independently...

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Bibliographic Details
Main Authors: Yong Xu, Yu Li, Da Zhai, Chen Yan, Jingyan Liang, Taiga Ichinomiya, Tetsuya Hara, Chiaki Inadomi, Tao-Sheng Li
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Pulmonary Medicine
Subjects:
Mechanical ventilation
Tidal volume
Oxidative damage
Inflammatory response
Mechanotransduction
Online Access:https://doi.org/10.1186/s12890-023-02626-x

Internet

https://doi.org/10.1186/s12890-023-02626-x

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