Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model

Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model

An increasing body of evidence indicates a role for oligomers of the amyloid-β peptide (Aβ) in the neurotoxicity of this peptide and the pathology of Alzheimer's disease (AD). Several neurotoxic oligomeric forms of Aβ have been noted ranging from the larger Amyloid β-Derived Diffusible Ligands...

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Bibliographic Details
Main Authors: R. Scherzer-Attali, D. Farfara, I. Cooper, A. Levin, T. Ben-Romano, D. Trudler, M. Vientrov, R. Shaltiel-Karyo, D.E. Shalev, N. Segev-Amzaleg, E. Gazit, D. Segal, D. Frenkel
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Abeta
AD mouse model
Oligomers
Therapy
AD fly model
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000769

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http://www.sciencedirect.com/science/article/pii/S0969996112000769

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