Surveillance for Intracellular Antibody by Cytosolic Fc Receptor TRIM21
TRIM21 has emerged as an atypical Fc receptor that is broadly conserved and widely expressed in the cytoplasm of mammalian cells. Viruses that traffic surface-bound antibodies into the cell during infection recruit TRIM21 via a high affinity interaction between Fc and TRIM21 PRYSPRY domain. Followin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-11-01
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| Series: | Antibodies |
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| Online Access: | http://www.mdpi.com/2073-4468/5/4/21 |