Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer’s disease at CPT1A locus

Abstract Background Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the...

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Main Authors: Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Clinical Epigenetics
Subjects:
Epigenetics
Insulin resistance
Alzheimer’s disease
FHS
ROSMAP
DNA methylation
Online Access:https://doi.org/10.1186/s13148-023-01589-4

Internet

https://doi.org/10.1186/s13148-023-01589-4

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