Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo

Hedgehog Pathway Blockade Inhibits Melanoma Cell Growth in Vitro and in Vivo

Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma. We profiled a panel of human melanoma cell lines and control melanocytes for altered expression of hedgehog pathway members...

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Bibliographic Details
Main Authors: Eva Hernando, Anna Pavlick, Jiri Zavadil, Judy Zhong, Sung Won Han, Laura Poliseno, Erica Friedman, Miguel F. Segura, Kathryn E. O'Reilly, Eleazar Vega-Saenz de Miera, Iman Osman
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Pharmaceuticals
Subjects:
melanoma
hedgehog
Smoothened
GLI2
PTCH1
Online Access:http://www.mdpi.com/1424-8247/6/11/1429

Internet

http://www.mdpi.com/1424-8247/6/11/1429

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