Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Eribulin induces micronuclei and enhances the nuclear localization of cGAS in triple-negative breast cancer cells

Abstract Eribulin (ERI), clinically utilized for locally advanced or metastatic breast tumors, has shown potential links to the immune system. Notably, the cGAS-STING pathway, a key component of innate immunity, has gained prominence. Yet, limited reports explore ERI's effects on the cGAS-STING...

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Bibliographic Details
Main Authors: Hideyuki Yamada, Mamoru Takada, Dhaval Ghone, Muhan Yu, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Yoshie Hasegawa, Shintaro Takao, Akimitsu Yamada, Kazutaka Narui, Takashi Ishikawa, Aussie Suzuki, Masayuki Otsuka
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-64651-y

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https://doi.org/10.1038/s41598-024-64651-y

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