The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis

The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis

Background: Osteoarthritis (OA) is a chronic degenerative joint disease that primarily affects middle-aged and elderly individuals. The decline in chondrocyte function plays a crucial role in the development of OA. Inflammasome-mediated chondrocyte pyroptosis is implicated in matrix degradation and...

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Bibliographic Details
Main Authors: Hao Tang, Xiaoshan Gong, Jingjin Dai, Jun Gu, Zicai Dong, Yuan Xu, Zhaoyang Hu, Chunrong Zhao, Jiezhong Deng, Shiwu Dong
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Orthopaedic Translation
Subjects:
ECM
GBP5
IRF1
NLRP3 inflammasome
OA
Pyroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000943

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http://www.sciencedirect.com/science/article/pii/S2214031X23000943

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