Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

Abstract Background Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the dystrophin gene), which is the most common and severe of the muscular dystrophies. To our knowledge, the distribution of iron, an important modulator of oxidative...

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Bibliographic Details
Main Authors: Francesca M. Alves, Kai Kysenius, Marissa K. Caldow, Justin P. Hardee, Jin D. Chung, Jennifer Trieu, Dominic J. Hare, Peter J. Crouch, Scott Ayton, Ashley I. Bush, Gordon S. Lynch, René Koopman
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Muscular dystrophy
Muscle metabolism
Iron
Oxidative stress
Online Access:https://doi.org/10.1002/jcsm.12950

Internet

https://doi.org/10.1002/jcsm.12950

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