Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens
Cyclic nucleotide binding domains (CNB) confer allosteric regulation by cAMP or cGMP to many signaling proteins, including PKA and PKG. PKA of phylogenetically distant Trypanosoma is the first exception as it is cyclic nucleotide-independent and responsive to nucleoside analogues (Bachmaier et al.,...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2024-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/91040 |