Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

Cyclic nucleotide binding domains (CNB) confer allosteric regulation by cAMP or cGMP to many signaling proteins, including PKA and PKG. PKA of phylogenetically distant Trypanosoma is the first exception as it is cyclic nucleotide-independent and responsive to nucleoside analogues (Bachmaier et al.,...

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Bibliographic Details
Main Authors: Veronica Teresa Ober, George Boniface Githure, Yuri Volpato Santos, Sidney Becker, Gabriel Moya Munoz, Jérôme Basquin, Frank Schwede, Esben Lorentzen, Michael Boshart
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-03-01
Series:eLife
Subjects:
protein kinase A
nucleoside
cAMP
CNB domain
Trypanosoma
Leishmania
Online Access:https://elifesciences.org/articles/91040

Internet

https://elifesciences.org/articles/91040

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