High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells

Abstract Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many other cell types. Its extracellular domain can be found in circulation known as soluble endoglin (sENG). Levels of sENG are elevated i...

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Bibliographic Details
Main Authors: Clara Andersson-Rusch, Bin Liu, Ingrid Quist-Løkken, Paul D. Upton, Oddrun Elise Olsen, Hanne Hella, Xudong Yang, Zhen Tong, Nicholas W. Morrell, Toril Holien, Wei Li
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33352-3