Synthesis, antifungal activity and in vitro mechanism of novel 1-substituted-5-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives

Synthesis, antifungal activity and in vitro mechanism of novel 1-substituted-5-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives

Inspired by the wide application of amides in plant pathogens, a series of novel 1-substituted-5-trifluoromethyl‑1H‑pyrazole-4-carboxamide derivatives were designed and synthesized. Bioassay results indicated that some target compounds exhibited excellent and broad-spectrum in vitro and certain in v...

Full description

Bibliographic Details
Main Authors:	Jingxin Yang, Dewen Xie, Chengzhi Zhang, Cailong Zhao, Zhibing Wu, Wei Xue
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Series:	Arabian Journal of Chemistry
Subjects:	Pyrazole carboxamides Molecular design Fungicidal activity Molecular docking SAR analysis Antifungal mechanism
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535222003033

Similar Items

Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate
by: Jialong Sun, et al.
Published: (2015-03-01)

Facile Syntheses and Molecular-Docking of Novel Substituted 3,4-Dimethyl-1H-pyrrole-2-carboxamide/carbohydrazide Analogues with Antimicrobial and Antifungal Properties
by: Jitendra D. Bhosale, et al.
Published: (2018-04-01)

5-Acetamido-1H-pyrazole-4-carboxamide monohydrate
by: Lhoussaine El Ghayati, et al.
Published: (2016-06-01)

Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide Derivatives
by: Zhibing Wu, et al.
Published: (2012-11-01)

Synthesis and Biological Evaluation of Novel Benodanil-Heterocyclic Carboxamide Hybrids as a Potential Succinate Dehydrogenase Inhibitors
by: Jian Yang, et al.
Published: (2020-09-01)

Novel aromatic carboxamides from dehydroabietylamine as potential fungicides: Design, synthesis and antifungal evaluation
by: Zihui Yang, et al.
Published: (2022-12-01)

Design, Synthesis, and Antifungal/Anti-Oomycete Activities of Novel 1,2,4-Triazole Derivatives Containing Carboxamide Fragments
by: Jiali Wang, et al.
Published: (2024-02-01)

Synthesis and anti-nociceptive potential of isoxazole carboxamide derivatives
by: Hajira Bibi, et al.
Published: (2019-01-01)

Antifungal Activities of Fluorinated Pyrazole Aldehydes on Phytopathogenic Fungi, and Their Effect on Entomopathogenic Nematodes, and Soil-Beneficial Bacteria
by: Vesna Rastija, et al.
Published: (2023-05-01)

Synthesis, In Silico Studies, and Antioxidant and Tyrosinase Inhibitory Potential of 2-(Substituted Phenyl) Thiazolidine-4-Carboxamide Derivatives
by: Muhammad Kazim Zargaham, et al.
Published: (2023-06-01)

Synthesis, DFT, Molecular docking Analysis and Antibacterial, Antioxidant Activities of tri-substituted pyrazoles
by: Golea Lynda
Published: (2021-07-01)

Synthesis, Antifungal Activity and Structure-Activity Relationships of Novel 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic Acid Amides
by: Shijie Du, et al.
Published: (2015-05-01)

Design, Synthesis, and Antifungal Activity of <i>N</i>-(alkoxy)-Diphenyl Ether Carboxamide Derivates as Novel Succinate Dehydrogenase Inhibitors
by: Bo He, et al.
Published: (2023-12-01)

New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties
by: Yassine Kaddouri, et al.
Published: (2022-06-01)

Novel Coumarin 7-Carboxamide/Sulfonamide Derivatives as Potential Fungicidal Agents: Design, Synthesis, and Biological Evaluation
by: Shu-Guang Zhang, et al.
Published: (2022-10-01)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus
by: Yaqing Jiao, et al.
Published: (2017-05-01)

Design and synthesis of novel substituted pyrazole as small molecule inhibitor of cytochrome P450 CYP121A1
by: Mitali Jasani, et al.
Published: (2023-01-01)

Synthesis, characterization, antimicrobial activity, and in silico assessment of a novel pyrazoline carboxamide heterocyclic compound
by: Farouk Boudou, et al.
Published: (2023-12-01)

Synthesis, characterization, antimicrobial activity, and in silico assessment of a novel pyrazoline carboxamide heterocyclic compound
by: Farouk Boudou, et al.
Published: (2023-12-01)

Synthesis, characterization, antimicrobial activity, and in silico assessment of a novel pyrazoline carboxamide heterocyclic compound
by: Farouk Boudou, et al.
Published: (2023-12-01)

Crystal structure and molecular docking studies of new pyrazole-4-carboxamides
by: Qiao Li, et al.
Published: (2019-05-01)

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors
by: Yazgı Dizdaroglu, et al.
Published: (2020-01-01)

Synthesis, DFT investigations, antioxidant, antibacterial activity and SAR-study of novel thiophene-2-carboxamide derivatives
by: Heba M. Metwally, et al.
Published: (2023-02-01)

Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing Phenylethynyl Pyrazole Side Chains
by: Tingjunhong Ni, et al.
Published: (2022-05-01)

DFT Study of Regio- and Stereoselective 13DC Reaction between Diazopropane and Substituted Chalcone Derivatives: Molecular Docking of Novel Pyrazole Derivatives as Anti-Alzheimer’s Agents
by: Sadeq M. Al-Hazmy, et al.
Published: (2023-02-01)

Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects
by: Belgin Sever, et al.
Published: (2020-10-01)

Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors
by: Belma Zengin Kurt, et al.
Published: (2017-01-01)

(<i>S</i>)-<i>N</i>-Benzyl-1-phenyl-3,4-dihydroisoqunoline-2(1<i>H</i>)-carboxamide Derivatives, Multi-Target Inhibitors of Monoamine Oxidase and Cholinesterase: Design, Synthesis, and Biological Activity
by: Qing-Hao Jin, et al.
Published: (2023-02-01)

Design, Synthesis, and Antifungal Activity of 4-Amino Coumarin Based Derivatives
by: Lu Xu, et al.
Published: (2022-04-01)

Design, Synthesis, and Bioactivity Evaluation of New Thiochromanone Derivatives Containing a Carboxamide Moiety
by: Lingling Xiao, et al.
Published: (2021-07-01)

Design, Synthesis and Anti-Tobacco Mosaic Virus (TMV) Activity of 5-Chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-yl)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide Derivatives
by: Jin-Jing Xiao, et al.
Published: (2015-01-01)

Bioactive molecular family construction: Design, optimization and antifungal mechanism study of novel 2-phenylglycine derivatives
by: Cailong Zhao, et al.
Published: (2023-12-01)

Synthesis and anti-inflammatory activity of some new 1,3,4-thiadiazoles containing pyrazole and pyrrole nucleus
by: S. Maddila, et al.
Published: (2016-09-01)

In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC—Application towards Cancer Therapeutics
by: Fatima Ezzahra Bennani, et al.
Published: (2022-10-01)

Rotenone enhances antifungal activity of novel pyrazoles against Candida spp.
by: Luis Fernando Quejada, et al.
Published: (2022-08-01)

Synthesis and properties of some 3-(5-(4-methoxyphenyl)pyrazol-3-yl)-6-R-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles
by: S. O. Fedotov, et al.
Published: (2022-08-01)

Molecular Characterization and Antifungal Susceptibility of Clinical Fusarium Species From Brazil
by: Patricia F. Herkert, et al.
Published: (2019-04-01)

Synthesis and biological evaluation of 1-(5-(2-chloroquinolin-3-yl)-3-phenyl-1H-pyrazol-1-yl)ethanone derivatives as potential antimicrobial agents
by: Pankaj B. Miniyar, et al.
Published: (2015-11-01)

Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides
by: Manuel Velasco, et al.
Published: (2022-07-01)

Design, synthesis, and molecular docking of cysteine-based sulphonamide derivatives as antimicrobial agents
by: Melford C Egbujor, et al.
Published: (2022-01-01)