BRAF-activated WT1 contributes to cancer growth and regulates autophagy and apoptosis in papillary thyroid carcinoma

BRAF-activated WT1 contributes to cancer growth and regulates autophagy and apoptosis in papillary thyroid carcinoma

Abstract Background Papillary thyroid carcinoma (PTC) is one of most prevalent malignant endocrine neoplasms, and it is associated with a high frequency of BRAF gene mutations, which lead to lymphatic metastasis and distant metastasis that promote tumor progression. The molecular mechanism of PTC an...

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Bibliographic Details
Main Authors: Xing Chen, Shan Lin, Ying Lin, Songsong Wu, Minling Zhuo, Ailong Zhang, Junjie Zheng, Zhenhui You
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Translational Medicine
Subjects:
PTC
WT1
Autophagy
Apoptosis
BRAFV600E
Online Access:https://doi.org/10.1186/s12967-022-03260-7

Internet

https://doi.org/10.1186/s12967-022-03260-7

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