Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

Persistent but dysfunctional mucosal SARS-CoV-2-specific IgA and low lung IL-1β associate with COVID-19 fatal outcome: A cross-sectional analysis

The role of the mucosal pulmonary antibody response in coronavirus disease 2019 (COVID-19) outcome remains unclear. Here, we found that in bronchoalveolar lavage (BAL) samples from 48 patients with severe COVID-19-infected with the ancestral Wuhan virus, mucosal IgG and IgA specific for S1, receptor...

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Bibliographic Details
Main Authors: Maria Julia Ruiz, Gabriel Siracusano, Andréa Cottignies-Calamarte, Daniela Tudor, Fernando Real, Aiwei Zhu, Claudia Pastori, Claude Capron, Arielle R. Rosenberg, Nigel Temperton, Diego Cantoni, Hanqing Liao, Nicola Ternette, Pierre Moine, Mathieu Godement, Guillaume Geri, Jean-Daniel Chiche, Djillali Annane, Elisabeth Cramer Bordé, Lucia Lopalco, Morgane Bomsel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
mucosal immunity
IgA
severe infection
inflammatory cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.842468/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.842468/full

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